منابع مشابه
The GABAergic system in schizophrenia.
A defect in neurotransmission involving gamma-amino butyric acid (GABA) in schizophrenia was first proposed in the early 1970s. Since that time, a considerable effort has been made to find such a defect in components of the GABAergic system. After a brief introduction focusing on historical perspectives, this paper reviews post-mortem and other biological studies examining the following compone...
متن کاملGABAergic Deficits in Schizophrenia: Evidence and Implications
Many biochemical theories have attempted to explain the pathophysiology of schizophrenia. The dopamine hypothesis is one of oldest and most popular biochemical theories, but it is too simplistic to account for all aspects of the illness. Other neurotransmitter systems, including glutamate, serotonin and -aminobutyric acid (GABA), have been implicated in schizophrenia. The role of the GABA syste...
متن کاملGABAergic Mechanisms in Schizophrenia: Linking Postmortem and In Vivo Studies
Schizophrenia is a psychiatric disorder characterized by hallucinations, delusions, disorganized thinking, and impairments in cognitive functioning. Evidence from postmortem studies suggests that alterations in cortical γ-aminobutyric acid (GABAergic) neurons contribute to the clinical features of schizophrenia. In vivo measurement of brain GABA levels using magnetic resonance spectroscopy (MRS...
متن کاملThe wandering of families with schizophrenia patient in a challenging support system and covid 19 crisis
Introduction: schizophrenia is a chronic condition that leads to debilitating consequences, is associated numerous challenges. So families need long-term psychosocial support. Methods: the study was performed by interpretive descriptive method. Using purposive sampling, 30 participants participated in the study. Data were collected through individual interviews and coded, codes with similar the...
متن کاملInvolvement of GABAergic System in Increased Pentylenetetrazole-Induced Seizure Threshold in Cholestatic Mice
Gamma-aminobutyric acid (GABA) is an important inhibitory transmitter in central nervous system and is involved in pathophysiology of epilepsy. Pentylenete-trazole (PTZ), a convulsant agent, partly acts via anion channel of GABAA receptor. Ivermectin, an antiparasitic agent and a GABAA agonist, has anticonvulsant effect in animal seizure models. Cholestasis increases ...
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ژورنال
عنوان ژورنال: The International Journal of Neuropsychopharmacology
سال: 2002
ISSN: 1461-1457,1469-5111
DOI: 10.1017/s1461145702002894